Plant defenses and resistance against pathogens can be affected by changing environmental conditions. Light is the major external factor affecting plant growth and development and influencing many other plant responses to the environment including defense against pests and pathogens. Potato cyst-forming nematode (PCN) Globodera rostochiensis Woll. is a widespread endoparasite of root system that causes significant reduction in potato yield in terms of quality and quantity. Under Nordic conditions potato crop is often subjected to a combination of low temperature and PCN invasion. The aim of the study was to investigate potato plant responses to a short-term temperature drop combined with PCN infestation under continuous lighting. Potato plants (‘Nevsky’) were grown under 24-h photoperiod. At the stage of 3 leaves plants were treated with a daily short temperature drop from 23 to 5°C for 2 h during 6 days. Control plants were grown under constant temperature of 23°C. Then plants were infested by potato cyst-forming nematode (10 cysts per plant) and maintained under 23°C with continuous light for 1 month. Drop-treated plants were more compact and had healthy (without light injury symptoms) leaves and higher plant developmental rate. Infestation by PCN also decreased plant height, but did not affect plant development. Nematode infestation had no effect on the maximum PSII efficiency of plants (Fv/Fm). Temperature drop treatment halved potato plant infestation by PCN. Possible mechanisms of plant cross-adaptation to biotic and abiotic stresses are discussed