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Малышева И.Е., Топчиева Л.В., Барышева О.Ю., Курбатова И.В., Васькова О.А., Везикова Н.Н., Марусенко И.М., Немова Н.Н.
Содержание цитокинов и уровень экспрессии генов каспаз при ревматоидном артрите
// Доклады академии наук. Биохимия, Биофизика, Молекулярная биология. Том 468, № 6. 2016. C. 707-709
I.E. Malysheva, L.V. Topchieva, O.Y. Barysheva, I.V. Kurbatova, O.A. Vasykova, N.N. Vezikova, I.M. Marusenko, N.N. Nemova. The level of cytokines and expression of caspase genes in rheumatoid arthritis // Doklady Biochemistry and Biophysics. Vol. 468, № 6. 2016. Pp. 707-709
The level of TNF α and IL6 in the blood plasma of patients with rheumatoid arthritis (RA) who received antiinflammatory therapy with methotrexate (MT) was significantly lower than in the patients with
out MT treatment. The level of caspase 6 and 9 gene transcripts in peripheral blood lymphocytes in patients
with rheumatoid arthritic diagnosed for the first time and in patients with MT treatment were not significantly
different. At the same time, the level of caspase 3 mRNA expression was significantly higher in the cells of the
RA patients with MT therapy compared to the patients without MT therapy.
out MT treatment. The level of caspase 6 and 9 gene transcripts in peripheral blood lymphocytes in patients
with rheumatoid arthritic diagnosed for the first time and in patients with MT treatment were not significantly
different. At the same time, the level of caspase 3 mRNA expression was significantly higher in the cells of the
RA patients with MT therapy compared to the patients without MT therapy.
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Last modified: September 27, 2016