Л.В. Топчиева, В.А. Корнева, О.В. Балан, И.Е. Малышева, И.В. Курбатова.
Липидный спектр у больных эссенциальной артериальной гипертензией и здоровых людей, имеющих разные аллельные вариации гена NOS2
// Труды КарНЦ РАН. No 3. Сер. Экспериментальная биология. 2020. C. 112-120
L.V. Topchieva, V.A. Korneva, O.V. Balan, I.E. Malysheva, I.V. Kurbatova. Lipid spectrum in patients with essential arterial hypertension and healthy people with different NOS2 gene allelic variations // Transactions of Karelian Research Centre of Russian Academy of Science. No 3. Experimental biology. 2020. Pp. 112-120
Keywords: blood plasma lipid spectrum;essentil aarterial hypertension; nitrogen oxide; NOS2 gene; allelic polymorphism
The plasma lipid profile was analyzed in healthy people and patients with essential arterial hypertension (EAH) (stages I–II) with different allelic variations in the inducible nitric oxide synthase (NOS2) gene polymorphic markers (rs1800482 and rs3730017). These polymorphic markers are associated with a change in the plasma level of nitric oxide. We found a positive correlation between nitric oxide plasma level and total cholesterol and low-density lipoprotein cholesterol content (ρ = 0.74 and 0.89, respectively). It was shown that patients with EAH carrying the C allele of rs1800482 had a lower level of high-density lipoprotein cholesterol compared to those with the GG genotype (p = 0.005). The atherogenic index was significantly higher in healthy and sick individuals carrying the C allele of the studied polymorphism (p = 0.04). The effect of the rs1800482 genotype on the high-density lipoprotein cholesterol content (Test statistic = 7.90; p = 0.0049) and the atherogenic index (Test statistic = 4.02; p = 0.045) was revealed. The data obtained indicate that the previously demonstrated high risk of EAG developing in individuals carrying the C allele of rs1800482 may be associated with a change in the plasma atherogenic and anti-atherogenic lipid fractions ratio.
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